The ICU studies we are currently recruiting for are as follows (Summer 2008):  

Protocol Name: Clinical Factors Associated with the development of severe sepsis in patients being treated for acute myeloid leukemia (AML).
Sponsor: NIH
PI: Naeem Ali, MD
Coordinator: Yahaira Kane
Synopsis: Observational Study. Subject population consists of patients admitted for inpatient therapy of AML. The protocol will investigate the role of hyperglycemia in the morbidity and mortality associated with AML treatment, and whether TSP-1 is important in modulating the course of sepsis induced acute lung injury.  Study procedures include CRF completion two blood draws: one at baseline and another at the onset of fever.

Protocol Name: Phase II Clinical Trial of Two Approaches to High Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome (HFOV)
Sponsor: NIH/Johns Hopkins University
PI: Scott Aberegg, MD/Naeem Ali, MD/James O’Brien, MD
Coordinator: Yahaira Kane
Synopsis: This is an exploratory clinical trial designed to characterized and compare clinical, physiologic, and biochemical responses of acute respiratory distress syndrome (ARDS) patients who receive two different approaches to the use of High Frequency Oscillatory Ventilation (HFOV). Enrolled subjects are randomized to one of 2 groups: 1) HFOV with higher airway pressures, and 2) HFOV with lower airway pressures.

Protocol Name: The Ohio State Sepsis Registry and Blood Bank
Sponsor: OSU Critical Care Center
PI: James O’Brien, MD/ Naeem Ali, MD
Coordinators: Luke Davis; Yahaira Kane; Anita Kapil;
Synopsis: Data collection of all septic patients in the OSUMC MICU consists of a one time blood draw and follow-up calls.  This data collection is not a primary research vehicle.  It is primarily intended to allow for determination of disparities and inadequacies of care for subsequent intervention.

Protocol Name: Blood Glucose Control in Adult and Pediatric Intensive Care Unit Patients Second Phase (Phase-2): Distribution and Implementation of Validated eProtocol-insulin in Naïve ICUs  (E-protocol)
Sponsor: OSU Critical Care Center
PI:  Naeem Ali, MD
Coordinator: Anita Kapil
Synopsis:  A research study to evaluate a computer program, called eProtocol-insulin that may help doctors and nurses take care of Intensive Care Unit (ICU) patients with high blood sugars. The Federal Food and Drug Administration (FDA) considers this computer program an investigational medical device.  This means that the computer program is a research tool that has not been cleared or approved for general patient use. The FDA has determined that eProtocol-insulin has no significant risks.

Protocol Name: Proteomic and the innate immune response in sepsis
Sponsor: OSU Critical Care Center
PI:  Mark Wewers, MD
Coordinators:  Luke Davis; Yahaira Kane; Anita Kapil;
Synopsis:  To evaluate specific protein and/or protein patterns that are involved in the immune response to sepsis.

Protocol Name: Clinical Determinants of Handgrip strength in critically ill adult’s pilot study
Sponsor: OSU Critical Care Center
PI: Naeem A. Ali, MD; James O’Brien, MD; Leanne K. Strack, DO 
Coordinators: Luke Davis; Yahaira Kane; Anita Kapil                                                                                     
Synopsis: To better understand ICU-acquired weakness in patients requiring mechanical ventilation in the Intensive Care Unit.  
 

Protocol Name: (ZEPHYR) Linezolid in the Treatment of Subjects with Nosocomial Pneumonia proven to be due to Methicillin- Resistant Staphylococcus Aureus.
Sponsor: Altana
PI: John Mastronarde, MD
Coordinator: Anita Kapil
Synopsis: To compare the clinical efficacy of Linezolid to Vancomycin in the treatment of Nosocomial pneumonia due to MRSA in hospitalized adults.