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Matthew Exline
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Home > Directory > Faculty > Matthew Exline

Matthew Exline, MD

Assistant Professor

 

201 Davis Heart and Lung Research Institute

473 West 12th Avenue
Columbus, OH 43210
Phone: (614) 247-7707


http://asthma.osu.edu/index.cfm

Clinical Interests
Sepsis

Pulmonary Infections
Mycobacterial Disease of the Lung


Research Interests
Sepsis
Inflammatory Mediators of Sepsis-induced Organ Failure
Apoptosis during Sepsis


Grants
2007-2008  American Lung Association Biomedical Research Grant
                 “Apoptosis in Sepsis:  The Role of Humanin, a Novel Anti-Apoptotic Peptide”

2007-2008  Davis Bremer Research Grant
                 “Integral Role of Apoptotic Enzyme Caspase-1 in Human Sepsis Severity”

Presentations

National Meetings:
Exline MC, Fahy RJ, Hall MW, Bhatt NY, Wewers MD.  Plasma Caspase-1 Levels Elevated in Patients with Septic Shock.  American Thoracic Society International Meeting, San Francisco, CA 2007.

Sarkar A, Hall MW, Exline MC, Hart J, Knatz N, Gatson N, Wewers MD.  Caspase-1 Knockout Prevents E.coli Induced Mortality and Splenic Cell Apoptosis Unlike IL-1? Knockout and IL-1?/IL-18 Double Knockout.  American Thoracic Society International Meeting, San Diego, CA 2006.

Exline MC, Fahy R, Gavrilin MA, Duncan MD, Wewers MD.  Anti-apoptotic Peptide Humanin Suppressed in Monocytes of Septic Patients.  American Thoracic Society Internation Meeting, San Diego, CA 2006.

Exline MC, Mastronarde JG.  Pulmonary Renal Syndrome Seropositive For Both Antineutrophil Cytoplasmic Autoantibodies And Anti-Glomerular Basement Membrane Autoantibodies.  American College of Chest Physicians National Meeting, Montreal 2005.

Exline MC, Sood N.  Pulmonary Arterial Hypertension:  An Unusual Presentation of Hodgkin’s Disease.  American College of Chest Physicians National Meeting, Montreal 2005.


Regional Meetings:
Ohio Thoracic Society Meeting; Salt Fork, OH 9/2004.  “Catastrophic Antiphospholipid Antibody Syndrome.”

 

Local Presentations:

Exline MC, Fahy RJ, Hall MW, Bhatt NY, Wewers MD.  Plasma Caspase-1 Levels Elevated in Patients with Septic Shock.   DHLRI Research Retreat 2007. 
 
Exline MC, Fahy R, Gavrilin MA, Duncan MD, Wewers MD.  Anti-apoptotic Peptide Humanin Suppressed in Monocytes of Septic Patients.  Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine First Annual Research Day 2006.


Sarkar A, Hall MW, Exline MC, Hart J, Knatz N, Gatson N, Wewers MD.  Caspase-1 Knockout Prevents E.coli Induced Mortality and Splenic Cell Apoptosis Unlike IL-1? Knockout and IL-1?/IL-18 Double Knockout.  Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine First Annual Research Day 2006.


Exline MC, Fahy R, Gavrilin  MA, Duncan MD, Wewers MD.  Anti-apoptotic Peptide Humanin Suppressed in Monocytes of Septic Patients.  OSU Medical Center Research Day 2006

 

Issues in Pulmonary Disease 2006 (Ohio State University CME course); Columbus, OH 3/2006.  “Diagnostic Dilemma’s – Pulmonary Embolism.”

 

Exline MC , Gavrilin MA, Duncan M, Wewers MD.  Bax Partner, Humanin, Binds ProIL-1b and is Inducible in Human Monocytes by Endotoxin.  OSU Medical Center Research Day 2005.

 

Issues in Pulmonary Disease 2005 (Ohio State University CME course); Columbus, OH 2/2005.  “Wegener’s Granulomatosis presenting with Cerebral Hemorrhage.”

 

Ohio State Current Concepts in Respiratory Care; Columbus, OH 2/2004.  “Inhaled Nitric Oxide.”

 

Ohio State Internal Medicine Grand Rounds Columbus, OH 5/2003. “Dangerous Medicine: Misconceptions and Realities of Physician Health and Well-being.”

 

Publications
Manuscripts:
Sarkar A, Hall MW, Exline MC, et al. Caspase-1 Regulates E. coli Sepsis and Splenic B-Cell Apoptosis Independently of IL-1? and IL-18. Am J Respir Crit Care Med 2006;174:1003-1010.

Exline MC, Sood N.  Pulmonary Hypertension in Hodgkin’s Disease.  Thorax 2007;62(4):371.

Benninger C, Mastronarde JG, Exline MC.  A Case of Refractory Asthma.  Chest 2007. (in press)

Exline MC, Fahy RJ, Hall MW, Sarkar A, Bhatt NY, Phillips GS, Wewers MD.  Plasma Caspase-1 Concentrations are Elevated in Human Septic Shock.  Critical Care Medicine 2007. (in review)

Abstracts:
Exline MC, Fahy RJ, Hall MW, Bhatt NY, Wewers MD.  Plasma Caspase-1 Levels Elevated in Patients with Septic Shock.  Proceedings of the American Thoracic Society 2007; 175(abstracts issue): A440.

Exline MC,
Fahy R, Gavrilin MA, Duncan MD, Wewers MD.  Anti-apoptotic Peptide Humanin Suppressed in Monocytes of Septic Patients.  Proceedings of the American Thoracic Society (abstract issue) 3: A328 2006.


Exline MC
, Mastronarde JG.  Pulmonary Renal Syndrome Seropositive For Both Antineutrophil Cytoplasmic Autoantibodies And Anti-Glomerular Basement Membrane Autoantibodies.  Chest Oct 2005 (supplement) 128: 477S-478S.

 

Exline MC, Sood N.  Pulmonary Arterial Hypertension:  An Unusual Presentation of Hodgkin’s Disease.  Chest Oct 2005 (supplement) 128: 413S.

 

Awards

Outstanding Case Presentation Section Cancer Cases I -  CHEST 2005

 

Committees

2007-present  American Thoracic Society AII Assembly Program Committee

2006-present  American Thoracic Society AII Assembly Membership Committee
2005-06   OSU Critical Care CQMC Delegate

2005-06   OSU East ICU CQMC Delegate


Department of Internal Medicine http://www.internalmedicine.osu.edu
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