Mark D. Wewers, MD

Biographical Narrative

Dr. Wewers trained in pulmonary medicine under the direction of Dr. Roger C. Bone at the University of Arkansas for Medical Sciences and then completed a 5 year research experience in the Pulmonary Branch of the National Institutes of Health under the guidance of Dr. Ronald G. Crystal. He was recruited to the faculty of the Ohio State University in 1986 where he has been continously supported by extramural funds from the NIH for his work on lung innate immune function since 1989. In 1996 he was named Division Director of Pulmonary and Critical Care Medicine at Ohio State University and Deputy Director of the Davis Heart and Lung Research Institute in 1997 where he served as interim director from 2000-2002. In 2000 he was bestowed the honor of the John A. Prior Professorship. Dr. Wewers has been a frequent external reviewer for the NIH and served as a permanent member of the Lung Biology and Pathology A study section from 1996-2000. He currently serves as Associate Director of the Davis Heart and Lung Research Institute where he is active in graduate programs and directs an NIH T32 training program on the molecular mechanisms of lung inflammation.

Certifications

Chapters In Books

Wewers, M. D.; Bone, R. C. "Emphysema and Chronic Bronchitis." In Pulmonary Disease Reviews. Edited by Bone, R. C. 229-244. New York, NY: John Wiley and Sons, Inc. 1982.

Wewers, M. D.; Bone, R. C. "Diagnostic Procedures." In Pulmonary Disease: Focus on Clinical Diagnosis. Edited by Hiller, F. C.; Wilson, F.; Bone, R. C. 153-178. Garden City, NY: Medical Examination Publishing Co. 1983.

Wewers, M. D.; Bone, R. C. "Flexible Fiberoptic Bronchoscopy." In Pulmonary Disease: Focus on Clinical Diagnosis. Edited by Hiller, C.; Wilson, F.; Bone, R. C. 174-194. Garden City, NY: Medical Examination Publishing Co. 1983.

Wewers, M. D.. "Dyspnea and Cirrhosis." In Contemporary Internal Medicine. Edited by Bowen, J.; Mazzaferri, E. M. 70-81. New York, NY: Plenum Medical Book Co. 1988.

Wewers, M. D.; Gadek, J. E. "Proinflammatory Peptides." In The Lung: Scientific Foundations. Edited by Crystal, R. G.; West, J. B. 91-103. New York, NY: Raven Press, Ltd. 1991.

Wewers, M. D.. "Cytokines and Macrophages." In Cytokines in Health and Disease. Edited by Remick, D. G.; Kunkel, S. L. 327-351. New York, NY: Marcel Dekker, Inc. 1992.

Wewers, M. D.. "Augmentation of Liver Production." In Lung Biology in Health and Disease Volume 88; Alpha 1-antirypsin Deficiency: Biology, Pathogenesis, Clinical Manifestations, Therapy. Edited by Crystal, R. G. 333-340. New York, NY: Marcell Dekker, Inc. 1996.

Wewers, M. D.. "Cytokines and Macrophages." In Cytokines in Health & Disease. Edited by Remick/Friedland. Chapter 23: 339-355. New York, NY: Marcel Dekker, Inc. 1996.

Marsh, C. B.; Wewers, M. D.. "The Pathogenesis of Sepsis: Factors that Modulate the Response to Gram-Negative Bacterial Infection." In Clinics in Chest Medicine. 2 ed. Vol. 17. Edited by Dorinsky, P. M. 183-197. Philadelphia, PA: W. B. Saunders Co. 1996.

Wewers, M. D.; Gadek, J. E.; Marsh, C. B. "Proinflammatory Cytokines." In The Lung: Scientific Foundations. 2nd ed. Edited by Crystal, R. G.; West, J. B.; Barnes, P. J.; Weibel, E. R. 117-132. New York, NY: Raven Press, Ltd. 1997.

Clinical Interests

Alpha 1-antitrypsin deficiency

Sepsis

Lung inflammation

Emphysema

Degrees

Editor Reviewed Journal Articles

Wewers, M.D., Gadek, J.E. "The protease theory of emphysema." Annals of Internal Medicine. Vol. 107 (1987): 761-763.

Editorial Activities

Ad Hoc Reviewer

Associate Editor

Journal Reviewer

Peer Manuscript Reviewer

Fellowship, Internship or Residency

Grants

Research Grant

Funded

Pending

Unfunded

Training Grant

Funded

Honors

Licensure

Memberships

Outreach

NetWellness
Project Dates: 2008 - present
Description: Provides online medical assistance to the public with concerns or questions about their lung health.

Peer Reviewed Journal Articles

Hiller, F. C.; Lucas, E. A.; Phillips, J. R.; Wewers, M. D.. 1980. Medical grand rounds: sleep apnea syndrome.  The Journal of the Arkansas Medical Society. Vol. 76, no. 10 (1980): 391-398.

Wewers, M. D.; Hiller, F. C.; Wilson, F. J.; Bone, R. C. "Haemophilus influenzae infection of an existing lung cyst."Southern Medical Journal. Vol. 75, no. 6 (1982): 736-737.

Wewers, M. D.; Rennard, S. I.; Hance, A. J.; Bitterman, P. B.; Crystal, R. G. "Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin-1."The Journal of Clinical Investigation. Vol. 74, no. 6 (1984): 2208-2218.

Pelham, F.; Wewers, M. D.; Crystal, R. G.; Buist, S. A.; Janoff, A. "Urinary excretion of desmosine (elastin crosslinks) in subjects with PiZZ alpha-1-antitrypsin deficiency, a phenotype associated with hereditary predisposition to pulmonary emphysema." American Review of Respiratory Disease. Vol. 132 (1985): 821-823.

Straus, S.D.; Fells, G.A.; Wewers, M.D.; Courtney, M.; Tessier, L.H.; Tolstoshev, P.; Lecocq, J.P.; Crystal, R.G. "Evaluation of recombinant DNA-directed E.coli produced alpha 1-antitrypsin as an anti-neutrophil elastase for potential use as replacement therapy of alpha 1-antitrypsin deficiency."Biochemical and Biophysical Research Communications. Vol. 130, no. 3 (1985): 1177-1184.

Wewers, M.D.; Gadek, J.E.; Keogh, B.A.; Fells, G. A.; Crystal, R. G. "Evaluation of danazol therapy for patients with PiZZ alpha-1-antitrypsin deficiency."The American Review of Respiratory Disease. Vol. 134, no. 3 (1986): 476-480.

Bitterman, P. B.; Wewers, M. D.; Rennard, S. I.; Adelberg, S.; Crystal, R. G. "Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators."The Journal of Clinical Investigation. Vol. 77, no. 3 (1986): 700-708.

Bitterman, P. B.; Rennard, S. I.; Keogh, B. A.; Wewers, M. D.; B. Adelberg, S; Crystal, R. G. "Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members."The New England Journal of Medicine. Vol. 314, no. 21 (1986): 1343-1347.

Wewers, M. D.; Casolaro, M. A.; Crystal, R. G. "Comparison of alpha-1-antitrypsin levels and antineutrophil elastase capacity of blood and lung in a patient with the alpha-1-antitrypsin phenotype null-null before and during alpha-1-antitrypsin augmentation therapy."The American Review of Respiratory Disease. Vol. 135, no. 3 (1987): 539-543.

Wewers, M. D.; Casolaro, M. A.; Sellers, S. E.; Swayze, S. C.; McPhaul, K. M.; Wittes, J. T.; Crystal, R. G. "Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema."The New England Journal of Medicine. Vol. 316, no. 17 (1987): 1055-1062.

Wewers, M. D.; Gadek, J. E. "The protease theory of emphysema."Annals of Internal Medicine. Vol. 107, no. 5 (1987): 761-763.

Wewers, M. D.; Saltini, C.; Sellers, S.; Tocci, M. J.; Bayne, E. K.; Schmidt, J. A.; Crystal, R. G. "Evaluation of alveolar macrophages in normals and individuals with active pulmonary sarcoidosis for the spontaneous expression of the interleukin-1 beta gene."Cellular Immunology. Vol. 107, no. 2 (1987): 479-488.

Wewers, M.D.; Brantly, M.L.; Casolaro, M.A.; Crystal, R.G. "Evaluation of tamoxifen as a therapy to augment alpha-1-antitrypsin concentrations in Z homozygous alpha-1-antitrypsin-deficient subjects."The American Review of Respiratory Disease. Vol. 135, no. 2 (1987): 401-402.

Casolaro, M.A.; Fells, G.; Wewers, M. D.; Pierce, J. E.; Ogushi, F.; Hubbard, R.; Sellers, S.; Forstrom, J.; Lyons, D.; Kawasaki, G. "Augmentation of lung antineutrophil elastase capacity with recombinant human alpha-1-antitrypsin."Journal of Applied Physiology (Bethesda, Md. : 1985). Vol. 63, no. 5 (1987): 2015-2023.

Wewers, M. D.; Herzyk, D. J.; Gadek, J. E. "Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin."The Journal of Clinical Investigation. Vol. 82, no. 4 (1988): 1260-1267.

Bernaudin, J.F.; Yamauchi, K.; Wewers, M. D.; Tocci, M. J.; Ferrans, V. J.; Crystal, R. G. "Demonstration by in situ hybridization of dissimilar IL-1 beta gene expression in human alveolar macrophages and blood monocytes in response to lipopolysaccharide."Journal of Immunology (Baltimore, Md. : 1950). Vol. 140, no. 11 (1988): 3822-3829.

Davis, W. B.; Husney, R. M.; Wewers, M. D.; Herzyk, D. J.; Sagone, A. L. "Effect of O2 partial pressure on the myeloperoxidase pathway of neutrophils."Journal of Applied Physiology (Bethesda, Md. : 1985). Vol. 65, no. 5 (1988): 1995-2003.

Wewers, M. D.; Herzyk, D. J. "Alveolar macrophages differ from blood monocytes in human IL-1 beta release. Quantitation by enzyme-linked immunoassay."Journal of Immunology (Baltimore, Md. : 1950). Vol. 143, no. 5 (1989): 1635-1641.

Wewers, M.D.; Herzyk, D. J.; Gadek, J.E. "Comparison of smoker and nonsmoker lavage fluid for the rate of association with neutrophil elastase."American Journal of Respiratory Cell and Molecular Biology. Vol. 1, no. 5 (1989): 423-429.

Wewers, M.D.. "Pathogenesis of emphysema. Assessment of basic science concepts through clinical investigation."Chest. Vol. 95, no. 1 (1989): 190.

Allen, J.N.; Wewers, M.D.. "HIV-associated bronchiolitis obliterans organizing pneumonia."Chest. Vol. 96, no. 1 (1989): 197-198.

Sagone, A. L. Jr; Husney, R.M.; Wewers, M. D.; Herzyk, D. J.; Davis, W. B. "Effect of dimethylthiourea on the neutrophil myeloperoxidase pathway."Journal of Applied Physiology (Bethesda, Md. : 1985). Vol. 67, no. 3 (1989): 1056-1062.

She, Z. W.; Wewers, M. D.; Herzyk, D. J.; Sagone, A. L.; Davis, W. B. "Tumor necrosis factor primes neutrophils for hypochlorous acid production."The American Journal of Physiology. Vol. 257, no. 6 Pt 1 (1989): L338-L345.

Wewers, M. D.; Rinehart, J. J.; She, Z. W.; Herzyk, D. J.; Hummel, M. M.; Kinney, P. A.; Davis, W. B. "Tumor necrosis factor infusions in humans prime neutrophils for hypochlorous acid production."The American Journal of Physiology. Vol. 259, no. 4 Pt 1 (1990): L276-L282.

Allen, J.N.; Wewers, M.D.. "Acute myocardial infarction with cardiogenic shock during pregnancy: treatment with intra-aortic balloon counterpulsation."Critical Care Medicine. Vol. 18, no. 8 (1990): 888-889.

Anderson, C. L.; Shen, L.; Eicher, D. M.; Wewers, M. D.; Gill, J. K. "Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes."The Journal of Experimental Medicine. Vol. 171, no. 4 (1990): 1333.

Allen, J. N.; Herzyk, D. J.; Wewers, M. D.. "Colchicine has opposite effects on interleukin-1 beta and tumor necrosis factor-alpha production."The American Journal of Physiology. Vol. 261, no. 4 Pt 1 (1991): L315.

Allen, J. N.; Herzyk, D. J.; Allen, E. D.; Wewers, M. D.. "Human whole blood interleukin-1-beta production: kinetics, cell source, and comparison with TNF-alpha."The Journal of Laboratory and Clinical Medicine. Vol. 119, no. 5 (1992): 538-546.

Herzyk, D. J.; Allen, J. N.; Marsh, C. B.; Wewers, M. D.. "Macrophage and monocyte IL-1 beta regulation differs at multiple sites. Messenger RNA expression, translation, and post-translational processing."Journal of immunology (Baltimore, Md. : 1950). Vol. 149, no. 9 (1992): 3052.

Herzyk, D. J.; Berger, A. E.; Allen, J. N.; Wewers, M. D.. "Sandwich ELISA formats designed to detect 17 kDa IL-1 beta significantly underestimate 35 kDa IL-1 beta."Journal of Immunological Methods. Vol. 148, no. 1-2 (1992): 243-254.

Wewers, M.D.; Pope, H.A.; Miller, D.K. "Processing proIL-1 beta decreases detection by a proIL-1 beta specific ELISA but increases detection by a conventional ELISA."Journal of Immunological Methods. Vol. 165, no. 2 (1993): 269.

Allen, J. N.; Moore, S. A.; Wewers, M. D.. "Taxol enhances but does not induce interleukin-1 beta and tumor necrosis factor-alpha production."The Journal of Laboratory and Clinical Medicine. Vol. 122, no. 4 (1993): 374.

Diaz, P. T.; Julian, M. W.; Wewers, M. D.; Clanton, T. L. "Tumor necrosis factor and endotoxin do not directly affect in vitro diaphragm function."The American Review of Respiratory Disease. Vol. 148, no. 2 (1993): 281-287.

Herzyk, D. J.; Wewers, M. D.. "ELISA detection of IL-1 beta in human sera needs independent confirmation. False positives in hospitalized patients."The American Review of Respiratory Disease. Vol. 147, no. 1 (1993): 139.

Kindt, G. C.; Moore, S. A.; She, Z. W.; Wewers, M. D.. "Endotoxin priming of monocytes augments Fc gamma receptor cross-linking-induced TNF-alpha and IL-1 beta release."The American Journal of Physiology. Vol. 265, no. 2 Pt 1 (1993): L178-L185.

She, Z. W.; Wewers, M. D.; Herzyk, D. J.; Davis, W. B. "Tumor necrosis factor increases the elastolytic potential of adherent neutrophils: a role for hypochlorous acid."American Journal of Respiratory Cell and Molecular Biology. Vol. 9, no. 4 (1993): 386-392.

Marsh, C, B; Wewers, M D.. "Cytokine-induced interleukin-1 receptor antagonist release in mononuclear phagocytes."American journal of respiratory cell and molecular biology. Vol. 10, no. 5 (1994): 521.

Marsh, C. B.; Moore, S. A.; Pope, H. A.; Wewers, M. D.. "IL-1ra suppresses endotoxin-induced IL-1 beta and TNF-alpha release from mononuclear phagocytes."The American Journal of Physiology. Vol. 267, no. 1 Pt 1 (1994): L39.

Marsh, C. B.; Pope, H. A.; Wewers, M. D.. "Fc gamma receptor cross-linking down-regulates IL-1 receptor antagonist and induces IL-1 beta in mononuclear phagocytes stimulated with endotoxin or Staphylococcus aureus."Journal of Immunology (Baltimore, Md. : 1950). Vol. 152, no. 9 (1994): 4604-4611.

Overdahl, M. C.; Wewers, M. D.. 1994. Acute occlusion of a mainstem bronchus by a rapidly expanding foreign body.  Chest. Vol. 105, no. 5 (1994): 1600-1602.

Wewers, M.D.. 1995. Pathogenesis of emphysema: Assessment of basic science concepts through clinical investigation.  Chest. Vol. 95 (1995): 190-195.

Allen, J. N.; Moore, S. A.; Pope-Harman, A. L.; Marsh, C. B.; Wewers, M. D.. "Immunosuppressive properties of surfactant and plasma on alveolar macrophages."The Journal of Laboratory and Clinical Medicine. Vol. 125, no. 3 (1995): 356.

Altenberger, E. A.; Pope, H. A.; Wewers, M. D.. 1995. Detection of soluble type II receptor in the presence of its natural ligand IL-1 beta. Quantification by sandwich ELISA.  Journal of Immunological Methods. Vol. 185, no. 1 (1995): 115-122.

Knoell, D. L.; Wewers, M. D.. 1995. Clinical implications of gene therapy for alpha 1-antitrypsin deficiency.  Chest. Vol. 107, no. 2 (1995): 535-545.

Marsh, C. B.; Gadek, J.E.; Kindt, G. C.; Moore, S. A.; Wewers, M. D.. "Monocyte Fc gamma receptor cross-linking induces IL-8 production."Journal of Immunology (Baltimore, Md. : 1950). Vol. 155, no. 6 (1995): 3161.

O'Brien, J. M. Jr.; Wewers, M. D.; Moore, S. A.; Allen, J. N. 1995. Taxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion. A role for microtubules in the regulation of IL-1 beta production.  Journal of Immunology (Baltimore, Md. : 1950). Vol. 154, no. 8 (1995): 4113-4122.

Allen, J. N.; Liao, Z; Wewers, M. D; Altenberger, E. A; Moore, S. A; Allen, E. D. 1996. Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia.  The Journal of Allergy and Clinical Immunology. Vol. 97, no. 6 (1996): 1366-1374.

Brown, E. A.; Dare, H. A.; Marsh, C. B.; Wewers, M. D.. "The combination of endotoxin and dexamethasone induces type II interleukin 1 receptor (IL-1r II) in monocytes: a comparison to interleukin 1 beta (IL-1 beta) and interleukin 1 receptor antagonist (IL-1ra)."Cytokine. Vol. 8, no. 11 (1996): 828.

Marsh, C. B.; Wewers, M. D.. "The pathogenesis of sepsis. Factors that modulate the response to gram-negative bacterial infection."Clinics in Chest Medicine. Vol. 17, no. 2 (1996): 183.

Marsh, C. B.; Anderson, C. L.; Lowe, M. P.; Wewers, M. D.. 1996. Monocyte IL-8 release is induced by two independent Fc gamma R- mediated pathways.  Journal of Immunology (Baltimore, Md. : 1950). Vol. 157, no. 6 (1996): 2632-2637.

Pue, C. A.; Mortensen, R. F.; Marsh, C. B.; Pope, H. A.; Wewers, M. D.. 1996. Acute phase levels of C-reactive protein enhance IL-1 beta and IL-1ra production by human blood monocytes but inhibit IL-1 beta and IL-1ra production by alveolar macrophages.  Journal of Immunology (Baltimore, Md. : 1950). Vol. 156, no. 4 (1996): 1594-1600.

Wewers, M. D.; Dare, H. A.; Winnard, A. V.; Parker, J. M.; Miller, D. K. "IL-1 beta-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1 beta release limitation is ICE independent."Journal of Immunology (Baltimore, Md. : 1950). Vol. 159, no. 12 (1997): 5964.

Wewers, M. D.; Marsh, C. B. 1997. Role of the antibody in the pathogenesis of transplant vascular sclerosis: a hypothesis.  Transplant Immunology. Vol. 5, no. 4 (1997): 283-288.

Wewers, M.D.; Marsh, C. B. 1997. Role of antibody in transplant vascular sclerosis: a hypothesis.  Transplant Immunology. Vol. 5 (1997): 283-288.

Allen, J. N.; Moore, S. A.; Jurist, U.A.; Liao, Z.; Wewers, M. D.. "Changes in mononuclear phagocyte microtubule stbility and composition after endotoxin stimulation: ll. Changes in microtubule stability." American Journal of Respiratory Cell and Molecular Biology. Vol. 16 (1997): 127-132.

Allen, J. N.; Moore, S. A.; Liao, Z.; Wewers, M. D.. 1997. Changes in mononuclear phagocyte microtubules after endotoxin stimulation. I. Changes in microtubule stability.  American Journal of Respiratory Cell and Molecular Biology. Vol. 16, no. 2 (1997): 119-126.

Marsh, C. B.; Wewers, M. D.; Tan, L. C.; Rovin, B. H. "Fc(gamma) receptor cross-linking induces peripheral blood mononuclear cell monocyte chemoattractant protein-1 expression: role of lymphocyte Fc(gamma)RIII."Journal of immunology (Baltimore, Md. : 1950). Vol. 158, no. 3 (1997): 1078.

Ralston, D. R.; Marsh, C. B.; Lowe, M. P.; Wewers, M. D.. 1997. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors.  The Journal of Clinical Investigation. Vol. 100, no. 6 (1997): 1416-1424.

Wewers, M. D.; Diaz, P. T.; Wewers, M. E.; Lowe, M. P.; Nagaraja, H. N.; Clanton, T. L. "Cigarette smoking in HIV infection induces a suppressive inflammatory environment in the lung."American Journal of Respiratory and Critical Care Medicine. Vol. 158, no. 5 Pt 1 (1998): 1543-1549.

Knoell, D. L.; Ralston, D. R.; Coulter, K. R.; Wewers, M. D.. "Alpha 1-antitrypsin and protease complexation is induced by lipopolysaccharide, interleukin-1beta, and tumor necrosis factor-alpha in monocytes."American Journal of Respiratory and Critical Care Medicine. Vol. 157, no. 1 (1998): 246.

Marsh, C. B.; Lowe, M. P.; Rovin, B. H.; Parker, J. M.; Liao, Z.; Knoell, D. L.; Wewers, M D.. "Lymphocytes produce IL-1beta in response to Fcgamma receptor cross-linking: effects on parenchymal cell IL-8 release."Journal of Immunology (Baltimore, Md. : 1950). Vol. 160, no. 8 (1998): 3942-3948.

Wewers, M. D.; Winnard, A. V.; Dare, H. A. "Endotoxin-stimulated monocytes release multiple forms of IL-1 beta, including a proIL-1 beta form whose detection is affected by export."Journal of Immunology (Baltimore, Md. : 1950). Vol. 162, no. 8 (1999): 4858-4863.

Coulter, K. R.; Wewers, M. D.; Lowe, M. P.; Knoell, D. L. 1999. Extracellular regulation of interleukin (IL)-1beta through lung epithelial cells and defective IL-1 type II receptor expression.  American Journal of Respiratory Cell and Molecular Biology. Vol. 20, no. 5 (1999): 964-975.

Diaz, P. T.; King, M. A.; Pacht, E. R.; Wewers, M. D.; Gadek, J. E.; Neal, D.; Nagaraja, H. N.; Drake, J.; Clanton, T. L. "The pathophysiology of pulmonary diffusion impairment in human immunodeficiency virus infection."American Journal of Respiratory and Critical Care Medicine. Vol. 160, no. 1 (1999): 272.

Fahy, R. J.; Doseff, A. I.; Wewers, M. D.. 1999. Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1.  Journal of Immunology (Baltimore, Md. : 1950). Vol. 163, no. 4 (1999): 1755-1762.

Marsh, C. B.; Pomerantz, R. P.; Parker, J. M.; Winnard, A. V.; Mazzaferri, E. L. Jr.; Moldovan, N.; Kelley, T. W.; Beck, E.; Wewers, M. D.. "Regulation of monocyte survival in vitro by deposited IgG: role of macrophage colony-stimulating factor."Journal of immunology (Baltimore, Md. : 1950). Vol. 162, no. 10 (1999): 6217.

Coulter, K. R.; Allen, E. D.; Hart, J.; Wewers, M. D.; Castile, R. G.; Knoell, D. L. 2000. Induction of interleukin-8 release by lung epithelium with cystic fibrosis epithelial lining fluid is marginally affected by inhibitors of interleukin-1beta.  Pharmacotherapy. Vol. 20, no. 1 (2000): 64-74.

Diaz, P. T.; King, M. A.; Pacht, E. R.; Wewers, M. D.; Gadek, J. E.; Nagaraja, H. N.; Drake, J.; Clanton, T. L. "Increased susceptibility to pulmonary emphysema among HIV-seropositive smokers."Annals of Internal Medicine. Vol. 132, no. 5 (2000): 369.

Diaz, P.T.; King, E.R.; Wewers, M. D.; Gadek, J. E.; Neal, D.; Drake. J.; Clanton, T. L. 2000. HIV infection increases susceptibility to smoking-induced emphysema.  Chest. Vol. 117 (2000): 285S.

Cooper, M. A.; Fehniger, T. A.; Ponnappan, A.; Mehta, V.; Wewers, M. D.; Caligiuri, M. A. "Interleukin-1beta costimulates interferon-gamma production by human natural killer cells."European Journal of Immunology. Vol. 31, no. 3 (2001): 792-801.

Fahy, R. J.; Diaz, P. T.; Hart, J.; Wewers, M. D.. "BAL and serum IgG levels in healthy asymptomatic HIV-infected patients."Chest. Vol. 119, no. 1 (2001): 196-203.

Mehta, V. B.; Hart, J.; Wewers, M. D.. "ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage."The Journal of Biological Chemistry. Vol. 276, no. 6 (2001): 3820.

Swaan, P. W.; Knoell, D. L.; Helsper, F.; Wewers, M. D.. "Sequential processing of human ProIL-1beta by caspase-1 and subsequent folding determined by a combined in vitro and in silico approach."Pharmaceutical Research. Vol. 18, no. 8 (2001): 1083-1090.

Coulter, K. R.; Doseff, A. I.; Sweeney, P.; Wang, Y.; Marsh, C. B.; Wewers, M. D.; Knoell, D. L. "Opposing effect by cytokines on Fas-mediated apoptosis in A549 lung epithelial cells."American Journal of Respiratory Cell and Molecular Biology. Vol. 26, no. 1 (2002): 58-66.

Crouser, E. D.; Julian, M. W.; Joshi, M. S.; Bauer, J. A.; Wewers, M. D.; Hart, J. M.; Pfeiffer, D. R. "Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia."Critical Care Medicine. Vol. 30, no. 12 (2002): 2722-2728.

Tridandapani, S.; Siefker, K.; Teillaud, J.; Carter, J.; Wewers, M. D.; Anderson, C. L. "Regulated expression and inhibitory function of Fcgamma RIIb in human monocytic cells."The Journal of Biological Chemistry. Vol. 277, no. 7 (2002): 5082-5089.

Diaz, P. T.; Wewers, M. D.; Pacht, E.; Drake, J.; Nagaraja, H. N.; Clanton, T. L. "Respiratory Symptoms Among HIV-Seropositive Individuals." Chest. Vol. 123, no. 6 (2003): 1977-1982.

Doseff, A. I.; Baker, J. H. Jr.; Bourgeois, T. A.; Wewers, M. D.. "Interleukin-4-induced apoptosis entails caspase activation and suppression of extracellular signal-regulated kinase phosphorylation."American Journal of Respiratory Cell and Molecular Biology. Vol. 29, no. 3 Pt 1 (2003): 367.

Fahy, R. J.; Lichtenberger, F.; McKeegan, C. B.; Nuovo, G. J.; Marsh, C. B.; Wewers, M. D. . "The acute respiratory distress syndrome: a role for TGF-B1." American Journal of Respiratory Cell and Molecular Biology. Vol. 28(4) (2003): 499-503.

Spragg, R. G.; Lewis, J. F.; Wurst, W.; Hafner, D.; Baughman, R. P.; Wewers, M. D.; Marsh, J. J. "Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant."American Journal of Respiratory and Critical Care Medicine. Vol. 167, no. 11. (2003)

Wewers, M. D.. "Alpha 1-antitrypsin Deficiency: More than a Protease Imbalance?." Chest. Vol. 125 (2004): 1607-1609.

Wewers, M. D.. "IL-1beta: an endosomal exit."Proceedings of the National Academy of Sciences of the United States of America. Vol. 101, no. 28 (2004): 10241-10242.

Crouser, E. D.; Julian, M. W.; Huff, J. E.; Joshi, M. S.; Bauer, J. A.; Gadd, M. E.; Wewers, M. D.; Pfeiffer, D. R. "Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia."Critical Care Medicine. Vol. 32, no. 2 (2004): 478-488.

Diaz, P. T.; Wewers, M. D.; King, M.; Wade, J.; Hart, J.; Clanton, T. L. "Regional differences in emphysema scores and BAL glutathione levels in HIV-infected individuals."Chest. Vol. 126, no. 5 (2004): 1439-1442.

Elssner, A.; Carter, J. E.; Yunger, T. M.; Wewers, M. D.. "HIV-1 infection does not impair human alveolar macrophage phagocytic function unless combined with cigarette smoking."Chest. Vol. 125, no. 3 (2004): 1071-1076.

Elssner, A.; Doseff, A. I.; Duncan, M.; Kotur, M.; Wewers, M. D.. "IL-16 is constitutively present in peripheral blood monocytes and spontaneously released during apoptosis."Journal of Immunology (Baltimore, Md. : 1950). Vol. 172, no. 12 (2004): 7721-7725.

Elssner, A.; Duncan, M.; Gavrilin, M.; Wewers, M. D.. "A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release."Journal of Immunology (Baltimore, Md. : 1950). Vol. 172, no. 8. (2004)

Fang, H.; Pengal, R. A.; Cao, X.; Ganesan, L. P.; Wewers, M. D.; Marsh, C. B.; Tridandapani, S. "Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP."Journal of Immunology (Baltimore, Md. : 1950). Vol. 173, no. 1 (2004): 360-366.

Kim, H.; Hart, J.; Knatz, N.; Hall, M. W.; Wewers, M. D.. "JAK3 downregulates LPS-induced ICE activation by autocrine IL-10." Journal of Immunology. Vol. 172 (2004): 4948-4955.

Wewers, M. D.; Lemeshow, S.; Lehman, A.; Clanton, T. L.; Diaz, P. T. "Lung CD4 lymphocytes predict survival in asymptomatic HIV infection."Chest. Vol. 128, no. 4 (2005): 2262-2267.

Fahy, R. J.; Wewers, M. D.. "Pulmonary defense and the human cathelicidin hCAP18/LL37." Immunologic Research. Vol. 1(2) (2005): 75-89.

Voss, O. H.; Kim, S.; Wewers, M. D.; Doseff, A. I. 2005. Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3.  The Journal of Biological Chemistry. Vol. 280, no. 17 (2005): 17371-17379.

Gavrilin, M. A.; Bouakl, I. J.; Knatz, N. L.; Duncan, M. D.; Hall, M. W.; Gunn, J. S.; Wewers, M. D.. "Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release."Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 1 (2006): 141-146.

Magalang, U. J.; Rajappan, R.; Hunter, M. G.; Kutala, V. K.; Kuppusamy, P.; Wewers, M. D.; Marsh, C. B.; Parinandi, N. L. "Adiponectin inhibits superoxide generation by human neutrophils."Antioxidants & Redox Signaling. Vol. 8, no. 11-12 (2006): 2179-2186.

Parsa, K. V. L.; Ganesan, L. P.; Rajaram, M. V. S.; Gavrilin, M. A.; Balagopal, A.; Mohapatra, N. P.; Wewers, M. D.; Schlesinger, L. S.; Gunn, J. S.; Tridandapani, S. "Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP."PLoS Pathogens. Vol. 2, no. 7 (2006): e71.

Sarkar, A.; Duncan, M.; Hart, J.; Hertlein, E.; Guttridge, D. C; Wewers, M. D.. "ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions."Journal of Immunology (Baltimore, Md. : 1950). Vol. 176, no. 8 (2006): 4979-4986.

Sarkar, A.; Hall, M. W.; Exline, M. C.; Hart, J.; Knatz, N.; Gatson, N. T.; Wewers, M. D.. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18."American Journal of Respiratory and Critical Care Medicine. Vol. 174, no. 9. (2006)

Hall, M. W.; Gavrilin, M. A.; Knatz, N. L.; Duncan, M. D.; Fernandez, S. A.; Wewers, M. D.. "Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome."Pediatric Research. Vol. 62, no. 5. (2007)

Nicholas, C.; Batra, S.; Vargo, M. A.; Voss, O. H.; Gavrilin, M. A.; Wewers, M. D.; Guttridge, D.C.; Grotewold, E.; Doseff, A. I. "Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kB through the suppression of p65 phosphorylation." Journal of Immunology. (2007)

Seshadri, S.; Duncan, M. D.; Hart, J. M.; Gavrilin, M. A.; Wewers, M.D.. "Pyrin levels in human monocytes and monocyte derived macrophages modify IL-1ß processing and release." Journal of Immunology. (2007)

Crouser E. D.; Exline M. C.; Knoell, D. L.; Wewers, M. D.. "Sepsis: links between pathogen sensing and organ damage." Current Pharmaceutical Design. Vol. 14, no. 19 (2008): 1840-1852.

Fahy, R.J.; Exline, M.C.; Gavrilin, M.A.; Bhatt, N.Y.; Besecker, B.Y.; Sarkar, A.; Hollyfield, J.L.; Duncan, M.D.; Nagaraja, H.N.; Knatz, N.L.; Hall, M.; Wewers, M.D.. Inflammasome mRNA expression in human monocytes during early septic shock." American Journal of Respiratory and Critical Care Medicine. Vol. 177, no. 9 (2008): 983-988.

Butchar, J. P.; Cremer, T. J.; Clay, C. D.; Gavrilin, M. A.; Wewers, M. D.; Marsh, C. B.; Schlesinger, L. S.; Tridandapani, S. "Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion." PLoS ONE. Vol. 3, no. 8 (13 August 2008): e2924.

Raices, R. M.; Kannan, Y.; Sarkar, A.; Bellamkonda-Athmaram, V.; Wewers, M. D.. "A synergistic role for IL-1beta and TNFalpha in monocyte-derived IFNgamma inducing activity." Cytokine. Vol. 44, no. 2 (November 2008): 234-241.

Wewers, M.D.; Sarkar, A. P2x(7) receptor and macrophage function." Purinergic Signalling. Vol. 5, no. 2 (2009): 189-195.

Akhter, A.; Gavrilin, M. A.; Frantz, L.; Washington, S.; Ditty, C.; Limoli, D.; Day, C.; Sarkar, A.; Newland, C.; Butchar, J.; Marsh, C. B.; Wewers, M. D.; Tridandapani, S.; Kanneganti, T.; Amer, A. O. Caspase-7 Activation by the Nlrc4/ipaf Inflammasome Restricts Legionella pneumophila Infection." PLoS Pathogens. Vol. 5, no. 4 (2009): Article No.: e1000361.

Crouser, E. D.; Shao, G.; Julian, M. W.; Macre, J. E.; Shadel, G. S.; Tridandapani, S.; Huang, Q.; Wewers, M. D.;. "Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors." Critical Care Medicine. Vol. 37, no. 6 (2009): 2000-2009.

Crouser, E.D.; Culver, D. A.; Knox, K.S.; Julian, M.W.; Shao, G.; Abraham, S.; Liyanarachchi, S.; Macre, J.E.; Wewers, M.D.; Gavrilin, M. A.; Ross, P.; Abbas, A.; Eng, C. Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis." American Journal of Respiratory and Critical Care Medicine. Vol. 179, no. 10 (2009): 929-938.

Gavrilin, M. A.; Mitra, S.; Seshadri, S.; Nateri, J.; Berhe, F.; Hall, M. W.; Wewers, M. D.. Pyrin critical to macrophage IL-1beta response to Francisella challenge." Journal of Immunology. Vol. 182, no. 12 (2009): 7982-7989.

Raices, R.M.; Kannan, Y.; Bellamkonda-Athmaram, V.; Seshadri, S.; Wang, H.; Guttridge, D.C.; Wewers, M.D.. A novel role for IkappaB zeta in the regulation of IFN gamma production." PLoS One. Vol. 4, no. 8 (2009): e6776.

Sarkar, A.; Mitra, S.; Mehta, S.; Raices, R.; Wewers, M. D.. Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1." PLoS One. Vol. 4, no. 9 (2009): e7140.

Seshadri, S.; Kannan, Y.; Mitra, S.; Parker-Barnes, J.; Wewers, M. D.. MAIL Regulates Human Monocyte IL-6 Production." Journal of Immunology. Vol. 183, no. 8 (2009): 5358-5368.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 activation by the Nirc4/Ipaf inflammasome restricts Legionella pneumophila infection." PLoS Pathogens. Vol. 5, no. 4. (April 2009): e1000361.

Crouser ED, Shao G, Julian MW, Macre JE, Shadel GS, Tridandapani S, Huang Q, Wewers MD. "Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors." Critical Care Medicine. Vol. 37, no. 6. (June 2009): 2000-2009.

Hughes T, Becknell B, Freud AG, McClory S, Briercheck E, Yu J, Mao C, Giovenzana C, Nuovo G, Wei L, Zhang X, Gavrilin MA, Wewers MD, Caligiuri MA. "IL-1Beta selectively expands and sustains IL-22(+) immature human natural killer cells in secondary lymphoid tissue." Immunity. Vol. 32. (2010): 803-814.

Lamkanfi M, Sarkar A, Vitari AC, Amer A, Wewers MD, Tracey KJ, Kanneganti T-D, Dixit VM. "Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia." Journal of Immunology. Vol. 185. (2010): 4385-4392.

Marquardt DJ, Knatz NL, Wetterau LA, Wewers, MD, Hall MW. "Failure to recove somatotropic asix function is assoicated with mortality from pediatric sepsis-induced multiple organ dysfunction syndrome." Pediatric Critical Care Medicine. Vol. 11, no. 1. (2010): 18-25.

Marquardt, D. J.; Knatz, N. L.; Wetterau, L. A.; Wewers, M. D.; Hall, M. W. "Failure to recover somatotropic axis function is associated with mortality from pediatric sepsis-induced multiple organ dysfunction syndrome." Pediatric Critical Care Medicine. Vol. 11, no. 1 (2010): 18-25.

Miao EA, Leaf IA, Treuting P, Mao DP, Dors M, Sarkar A, Wewers MD, Aderem A. "Caspase-1 induced pyroptosis clears intracellular bacteria independent of IL-1Beta/IL-18 in vivo." Nature Immunology. Vol. 11, no. 12. (2010): 1136-1142.

Zakharova, E.; Grandhi, J.; Wewers, M. D.; Gavrilin, M. A. Mycoplasma suppression of THP-1 cell TLR responses is corrected with antibiotics." PLoS One. Vol. 5, no. 3 (2010): Article No.: e9900.

Kannan Y, Yu J, Raices RM, Seshadri S, Wei M, Caligiuri M, Wewers, MD. "ικβζ augments IL-12 and IL-18 mediated IFN-γ production in human NK cells." Blood. Vol. 117, no. 10. (2011): 2855-2863.

Dalia H. Abdelaziz, Mikhail A. Gavrilin, Anwari Akhter, Kyle Caution, Sheetal Kotrange, Arwa Abu Khweek, Basant A. Abdulrahman, Jaykumar Grandhi, Zeinab A. Hassan, Clay Marsh, Mark D. Wewers, Amal O. Amer. "ASC controls legionella pneumophila infection in human monocytes." Journal of Biological Chemistry. Vol. 286, no. 5. (February 2011): 3203-3208.

Hall MW, Knatz NL, Vetterly C, Tomarello S, Wewers MD, Volk HD, Carcillo JA. "Immunoparalysis and nosocomial infection in children with multiple organ dysfunction." Intensive Care Medicine. Vol. 37, no. 3. (March 2011): 525-532.

Positions

Presentations

Invited Presentations

Regional

Mark D. Wewers, M.D., Lecturer. "Alpha 1-antitrypsin deficiency: diagnosis and treatment." Presented at Indiana American College of Physicians Annual Meeting. Indianapolis, Indiana. (1989)

Dr. Mark Damian Wewers. "Caspases: inflammatory and suicidal, State of the Art Lecture." Presented at Midwest American Federation for Medical Research. (September 19, 1998)

Dr. Mark Damian Wewers. "New Developments in the Treatment of Sepsis." Presented at OMEN-TV presentation. Columbus, Ohio. (April 3, 2002)

Mark D. Wewers, M.D., Lecturer. "Alpha 1-antitrypsin deficiency." Presented at MEDNET webcast. Columbus, OH. (2008)

National

Dr. Mark Damian Wewers, Presenter. "Alpha 1-antitrypsin deficiency - 15 years later." Presented at North American Society of Pediatric Gastroenterology. Chicago, IL. (November 1)

Dr. Mark Damian Wewers. "Re-establishment of the Anti-Elastase Screen of the Lower Respiratory Tract." Presented at American Thoracic Society, Symposium: Symposium on Alpha 1-antitrypsin Deficiency: From the Gene of the Bedside. Anaheim, CA. (May 1, 1985)

Dr. Mark Damian Wewers. "Interleukin 1 beta and Sarcoidosis." Presented at American Thoracic Society, Symposium: Sarcoidosis. New Orleans, LA. (May 1, 1987)

Dr. Mark Damian Wewers. "Pathogenesis of Emphysema: Assessment of Basic Concepts Through Clinical Investigations." Presented at American College of Chest Physicians, Symposium on Alpha 1-antitrypsin Deficiency. Atlanta, GA. (October 1, 1987)

Dr. Mark Damian Wewers. "Proteases and Their Effect on the Fragile Lung." Presented at American College of Allergy and Immunology. Los Angeles, CA. (November 1, 1988)

Dr. Mark Damian Wewers. "Interleukin 1 beta and the lung." Presented at American Thoracic Society, Symposium: Cytokines and Cytokine Networks in the Lung. Cincinnatti, OH. (May 1, 1989)

Dr. Mark Damian Wewers. "Recent Advances in the Treatment of Alpha-1-antitrypsin Deficiency and Future Advances on the Horizon." Presented at American College of Chest Physicians Annual Scientific Meeting. Boston, MA. (October 31, 1989)

Dr. Mark Damian Wewers. "Role of Alpha-1-antitrypsin in Cystic Fibrosis and Adult Respiratory Distress Syndrome." Presented at American College of Chest Physicians Annual Scientific Meeting, Symposium on New Concepts of Pathogenesis and Treatment of Emphysema. Orlando, FL. (October 28, 1993)

Dr. Mark Damian Wewers. "Pulmonary Vasculitis Update." Presented at Fifth Charleston Lung Symposium. Charleston, SC. (March 21, 1994)

Dr. Mark Damian Wewers. "New Concepts in IL-1ß Regulation: A receptor antagonist, an ICE inhibitor and a decoy receptor." Presented at American Thoracic Society International Symposium. Boston, MA. (May 22, 1994)

Dr. Mark Damian Wewers. "Role of epithelium in regulating alveolar macrophage HIV infection." Presented at National Heart Lung and Blood Institute RFA Meeting. Bethesda, MD. (September 20, 2000)

Dr. Mark Damian Wewers. "ICE: on the crossroads of apoptosis and inflammation." Presented at National Institute of Environmental Health Sciences; Research. Research Triangle Park. Research Triangle Park, North Carolina. (October 3, 2000)

International

Dr. Mark Damian Wewers. "Alveolar Macrophage IL-1 Regulation." Presented at American Thoracic Society International Conference. Miami, FL. (May 17, 1992)

Dr. Mark Damian Wewers. "Clinical Implications of alpha-1-antitrypsin Gene Therapy." Presented at International Symposium: Alpha-1-antitrypsin: A World View in 1994. Barcelona, Spain. (October 7, 1994)

Dr. Mark Damian Wewers. "Cytokines in Lung Inflammation." Presented at American Thoracic Society International Conference on Inflammatory Mechanisms in the Lung and Airways: Cells, Cytokines and Mediators. Seattle, WA. (May 20, 1995)

Dr. Mark Damian Wewers. "Postgraduate Course: Inflammatory Mechanisms in the Lung and Airways: Cells, Cytokines and Mediators, Cytokines in Airway Inflammation, Lung Injury, Lung Defense." Presented at American Thoracic Society International Conference. New Orleans, LA. (May 11, 1996)

Dr. Mark Damian Wewers. "Featured Speaker, Advances in Macrophage Biology, Macrophages and IL-1ß: Braking the ICE." Presented at American Thoracic Society International Conference. New Orleans, LA. (May 13, 1996)

Dr. Mark Damian Wewers. "Role of Antibody in Transplant Vascular Sclerosis." Presented at Second International Symposium on the Etiology and Pathobiology of Transplant Vascular Sclerosis. Southhampton, Bermuda. (March 8, 1997)

Dr. Mark Damian Wewers. "Caspases: executioners of apoptosis, Symposium Speaker." Presented at American Thoracic Society International Conference. San Diego, CA. (April 24, 1999)

Dr. Mark Damian Wewers. "Cytokines in Lung Inflammation Postgraduate Course 11: Inflammatory Mechanisms in the Lung and Airways: Cells, Cytokines and Mediators." Presented at American Thoracic Society International Conference. San Diego, CA. (April 24, 1999)

Dr. Mark Damian Wewers. "Cytokines in Lung Injury, Repair and Inflammation." Presented at American Thoracic Society International Conference. San Francisco, California. (May 19, 2001)

Dr. Mark Damian Wewers, Presenter. "Macrophages: Link Between Inflammation and Cell Death." Presented at Symposium on Macrophage Biology, American Thoracic Society International Conference. San Francisco, California. (May 20, 2001)

Dr. Mark Damian Wewers. "Minisymposium on HIV Infection and the Lung, HIV Interactions with Lung Inflammatory and Parenchymal Cells." Presented at American Thoracic Society International Conference. San Francisco, CA. (May 21, 2001)

Dr. Mark Damian Wewers. "CD4 lung lymphocytes predict survival in Asymptomatic HIV Infection." Presented at American Thoracic Society International Conference. Orlando, Florida. (May 26, 2004)

Mark D. Wewers, M.D., Presenter. "The inflammasome in the host defense response." Presented at Postgraduate Course: Lung innate immunity: the frontlines of host defense. American Thoracic Society International Conference. San Francisco, California. (May 2007)

Other Presentations

National

Dr. Mark Damian Wewers. "Pulmonary vascular disorders and sleep apnea." Presented at National Institute of Heath Internal Medicine Board Review Course. Bethesda, MD. (January 1, 1985)

Dr. Mark Damian Wewers. "ProIL-1ß Detection by ELISA." Presented at American Physiological Society Conference: Physiology of the Release and Activity of Cytokines, Yale University. New Haven, CT. (May 22, 1994)

Dr. Mark Damian Wewers. "Macrophages, role of smoking and emphysema." Presented at National Heart Lung and Blood Institute Workshop: Pulmonary Complications of HIV in the Era of HAART. Bethesda, MD. (October 25, 1999)

Professional Activities

Research